National Cancer Institute
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Cancer Prevention Study II Nutrition Cohort (CPS-II Nutrition)

Cohort Collaboration Contact

If interested in collaborating with the cohort on a project, please contact:

Principal Investigators

  • Susan Gapstur (American Cancer Society)
Cohort Website



The CPS-II Nutrition Cohort is an intensively studied sub-cohort of the 1.2 million person CPS-II Baseline Cohort that was enrolled in 1982. The CPS-II Nutrition Cohort is followed for cancer incidence and mortality. CPS-II Nutrition Cohort participants were enrolled in 1992 when they completed and returned an 8-10 page questionnaire providing detailed information on diet and other lifestyle factors. At enrollment, the CPS-II Nutrition Cohort included 184,194 men and women from the CPS-II Baseline Cohort who were aged 40-93 years and resided in 21 states with population-based state cancer registries. Since 1997, this sub-cohort has been re-contacted by mail biennially to obtain self-reported information on newly diagnosed cancers and additional exposure information. Self-reported cancer diagnoses are verified by medical record review. Linkage with state cancer registries is used when medical records cannot be obtained. The vital status of study participants is updated biennially through linkage with the NDI. In 1998, the CPS-II LifeLink Cohort was initiated to obtain blood samples from surviving members of the CPS-II Nutrition Cohort in 20 states who resided near blood collection centers at 312 collaborating community hospitals in urban or suburban areas. Blood samples were provided by 39,380 cohort members (30.5% of invited participants). Collection began in 1998 and was completed in 2001. The CPS-II Buccal Cell Cohort was initiated to obtain mouthwash (buccal cell) samples by mail from Nutrition Cohort participants who were unable (for geographic reasons) or unwilling to give a blood sample. Collection began in 2001 and was completed in 2002. Buccal cell samples were received from 70,004 participants (55% of invited participants). Collection of tumor specimens began in 2009 and is ongoing. Included in the collection are all available samples from 1992 onward for the breast, colon, hematologic, and prostate cancer sites.