National Cancer Institute
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Breast Cancer Family Registry Cohort (BCFR Cohort)

Cohort Collaboration Contact

If interested in collaborating with the cohort on a project, please contact:

Principal Investigators

  • Esther M. John, PhD, MSPH (Contact PI) (Cancer Prevention Institute of California)
  • Mary Beth Terry, PhD (Substitute PI) (Mailman School of Public Health)
  • Irene Andrulis, PhD (Samuel Lunenfeld Research Institute)
  • Mary Daly, MD, PhD (Fox Chase Cancer Center)
  • Saundra S. Buys, MD (University of Utah Health Sciences Center)
  • John L. Hopper, PhD (The University of Melbourne)
Cohort Website


The Breast Cancer Family Registry (BCFR) is an international resource of multi-generational families, data, and biospecimens established for interdisciplinary collaborative research on breast cancer, which is available to the entire scientific community. Over 40,000 women and men from nearly 15,000 families have generously contributed questionnaire data, clinical data and/or biospecimens. Over 150 individual investigators at all stages of their careers, from pre-doctoral students to full professors have used the BCFR resources (using over 200,000 biospecimen samples) since its inception, generating over 300 scientific publications.

The BCFR provides an extensive and diverse range of resources, expertise, and specialized skills, and has several unique strengths: 1) the collection of a large number of individuals and families across a wide spectrum of breast cancer risk, including both affected and unaffected individuals; 2) the large collection of families with early-onset breast cancer; 3) the large collection of racial/ethnic minority families not replicated elsewhere; 4) the extensive molecular characterization performed to date; and 5) active follow-up of both probands and family members. Thus, the BCFR comprises a unique cohort of probands and family members at familial/genetic risk of breast cancer that will continue to facilitate a wide range of research studies, such as gene discovery, examination of cancer-related outcomes and risk factors in high-risk subjects, investigation of novel behavioral interventions, and cancer prevention trials among at-risk family members. Consequently, the BCFR Cohort, as one of the few cohorts available worldwide with biospecimens and extensive molecular and genetic characterization combined with epidemiologic data and long-term follow up, will be an invaluable resource for translational research in the genetic epidemiology of breast cancer.